Ikhithi yoVavanyo ye-TT4

I-Thyroxine (T4), okanye i-3,5,3',5'-tetraiodothyronine, yi-hormone ye-thyroid enobunzima be-molecular malunga ne-777Da ekhutshwe kwi-circulation kwifomu yamahhala, ngaphezu kwe-99% ebophelelwe kwiiprotheni kwi-plasma kunye ixabiso elincinci kakhulu le-T4 yamahhala (FT4) engabotshwanga kwiiprotheni kwi-plasma.Imisebenzi ephambili ye-T4 ibandakanya ukugcina ukukhula kunye nophuhliso, ukukhuthaza imetabolism, ukuvelisa iziphumo ze-neurological kunye ne-cardiovascular effects, ukuchaphazela ukuphuhliswa kwengqondo, kwaye liyinxalenye yenkqubo yokulawula i-hormone ye-hypothalamic-pituitary-thyroid, enendima ekulawuleni umzimba womzimba.I-TT4 ibhekisa kwisixa se-thyroxine yasimahla kunye nebotshelelwe kwiserum.Uvavanyo lwe-TT4 lusetyenziswa kliniki njengoxilongo oluncedisayo lwe-thyroid dysfunction, kwaye ukwanda kwayo kubonakala ngokuqhelekileyo kwi-hyperthyroidism, i-subacute thyroiditis, i-serum ephezulu ye-thyroxine-binding globulin (TBG), kunye ne-thyroid hormone insensitivity syndrome;ukuncipha kwayo kubonakala kwi-hypothyroidism, ukusilela kwe-thyroid, i-lymphoid Goiter engapheliyo, njl.