Iprogesterone (P)

Iprogesterone yiprogestogen ebalulekileyo, eyeyehomoni ze-steroid, kunye nobunzima be-molecular of 314.5.Ininzi iveliswa yi-corpus luteum ye-ovary kunye ne-placenta ngexesha lokukhulelwa.Yi-precursor ye-testosterone, i-estrogen kunye ne-adrenal cortex hormone.Inqanaba leprogesterone eliveliswa ngexesha lesigaba se-follicular yamadoda aqhelekileyo kunye nabasetyhini liphantsi kakhulu, emva kokuphuma kwegazi, libotshelelwa ikakhulu kwi-albumin kunye nehomoni yesini ebopha iprotheni kunye nokujikeleza emzimbeni.

Umsebenzi oyintloko weprogesterone kukwenza isibeleko silungiselelwe ukufakelwa kwamaqanda achumileyo kunye nokugcina ukukhulelwa.Ngethuba lesigaba se-follicular somjikelezo wokuya esikhathini, inqanaba leprogesterone liphantsi.Emva kwe-ovulation, i-progesterone eveliswa yi-corpus luteum ikhula ngokukhawuleza, kwaye ifikelela kwi-concentration ephezulu ye-10ng / mL-20ng / mL kwiintsuku ze-5-7 emva kwe-ovulation.Ukuba ayikhawulwanga, i-corpus luteum atrophies ngexesha leentsuku ezine zokugqibela zomjikelo wokuya exesheni kunye noxinzelelo lweprogesterone lwehla kwisigaba se-follicular.Ukuba ikhulelwe, i-corpus luteum ayipheli kwaye iyaqhubeka nokukhupha i-progesterone, igcina kumanqanaba alingana nesigaba se-luteal esiphakathi kwaye iqhubeke kude kube yiveki yesithandathu yokukhulelwa.Ngethuba lokukhulelwa, i-placenta kancane kancane iba ngumthombo oyintloko weprogesterone, kwaye ukugxilwa kwanda ukusuka kwi-10ng / mL-50ng / mL kwiinyanga zokuqala ze-3 zokukhulelwa ukuya kwi-50ng / mL-280ng / mL kwiinyanga ezi-7-9.Izifundo zeklinikhi zibonise ukuba iprogesterone idlala indima ekukhuthazeni i-ovulation kunye nokugcina umsebenzi oqhelekileyo we-corpus luteum kubasetyhini abangakhulelwanga.Ukuba i-progesterone eveliswa yi-corpus luteum ayanelanga, ingabonisa ukuba umsebenzi we-corpus luteum awanelanga, kwaye umsebenzi we-corpus luteum owaneleyo unxulumene nokungabikho komntwana kunye nokuphuphuma kwesisu kwangaphambili.