Ngomhla we-17 kuCanzibe, ngo-2023 ngumhla we-19 "uSuku lweHlabathi loxinzelelo lwegazi".
Uxinzelelo lwegazi luyaziwa ngokuba "ngumbulali" wempilo yabantu.Ngaphezu kwesiqingatha sezifo ze-cardiovascular, strokes kunye nokuhluleka kwentliziyo kubangelwa yi-hypertension.Ke ngoko, sisenendlela ende ekufuneka siyihambile kuthintelo kunye nonyango loxinzelelo lwegazi.
01 Ukuxhaphaka kwehlabathi jikelele loxinzelelo lwegazi
Ehlabathini lonke, malunga ne-1.28 yebhiliyoni yabantu abadala abaneminyaka engama-30-79 abanesifo soxinzelelo lwegazi oluphezulu.Kuphela yi-42% yezigulana ezinoxinzelelo lwegazi eziye zafunyaniswa kwaye zinyangwa, kwaye malunga nesigulane esinye kwisihlanu esinoxinzelelo lwazo oluphantsi kolawulo.Ngo-2019, inani lokufa okubangelwa luxinzelelo lwegazi kwihlabathi liphela lidlule kwi-10 lezigidi, libalelwa kwi-19% yabo bonke abantu ababhubhileyo.
02 Yintoni Uxinzelelo lwegazi?
I-Hypertension yi-syndrome ye-cardiovascular syndrome ebonakaliswe ngokuqhubekayo amanqanaba oxinzelelo lwegazi kwimithambo yegazi.
Uninzi lwezigulane azinazo iimpawu okanye iimpawu ezicacileyo.Inani elincinci lezigulane ezinoxinzelelo lwegazi linokuba nesiyezi, ukudinwa okanye ukuphuma kwegazi ngeempumlo.Ezinye izigulana ezinoxinzelelo lwegazi lwe-systolic lwe-200mmHg okanye ngaphezulu zingenakho ukubonakaliswa okucacileyo kweklinikhi, kodwa intliziyo, ingqondo, izintso kunye nemithambo yegazi yonakaliswe kwinqanaba elithile.Njengoko isifo siqhubela phambili, izifo ezisongela ubomi ezifana nokungaphumeleli kwentliziyo, i-myocardial infarction, i-cerebral hemorrhage, i-cerebral infarction, ukungasebenzi kakuhle kwezintso, i-uremia, kunye ne-peripheral vascular occlusion iya kwenzeka ekugqibeleni.
(1) I-hypertension ebalulekileyo: i-akhawunti malunga ne-90-95% yezigulane ezixinzelelekileyo.Isenokunxulunyaniswa nezinto ezininzi ezinje ngemfuza, indlela yokuphila, ukutyeba, uxinzelelo kunye nobudala.
(2) I-hypertension yesibini: i-akhawunti malunga ne-5-10% yezigulane ezixinzelelekileyo.Kukunyuka kwengcinezelo yegazi ebangelwa zezinye izifo okanye iziyobisi, ezifana nesifo sezintso, ukuphazamiseka kwe-endocrine, isifo senhliziyo, imiphumo emibi yeziyobisi, njl.
03 Unyango lweziyobisi kwizigulane ezinoxinzelelo lwegazi
Imigaqo yonyango ye-hypertension yile: ukuthatha iyeza ixesha elide, ukulawula izinga loxinzelelo lwegazi, ukuphucula iimpawu, ukuthintela nokulawula iingxaki, njl. Amanyathelo onyango abandakanya ukuphuculwa kwendlela yokuphila, ulawulo lomntu ngamnye loxinzelelo lwegazi, kunye nokulawulwa kwezinto ezinobungozi bentliziyo, phakathi kwazo. Ukusetyenziswa kwexesha elide kwamachiza e-antihypertensive yeyona ndlela yonyango ibalulekileyo.
Iikliniki zihlala zikhetha indibaniselwano yamachiza ahlukeneyo asekelwe kwinqanaba loxinzelelo lwegazi kunye nomngcipheko we-cardiovascular wesigulane, kwaye udibanise unyango lwamachiza ukuphumeza ulawulo olululo loxinzelelo lwegazi.Amachiza e-antihypertensive asetyenziswa ngokuqhelekileyo zizigulane ziquka i-angiotensin-converting enzyme inhibitors (ACEI), i-angiotensin receptor blockers (ARB), i-β-blockers, i-calcium channel blockers (CCB), kunye ne-diuretics.
04 Uvavanyo lwemfuzo kusetyenziso lwechiza lomntu ngamnye kwizigulana ezinoxinzelelo lwegazi
Okwangoku, amachiza e-antihypertensive asetyenziswa rhoqo kwiklinikhi ngokubanzi anomahluko ngamnye, kwaye isiphumo sokunyanga samachiza oxinzelelo lwegazi sinxulunyaniswa kakhulu ne-polymorphisms yemfuzo.I-Pharmacogenomics inokucacisa ubudlelwane phakathi kwempendulo yomntu ngamnye kumachiza kunye nokwahluka kofuzo, njengempembelelo yonyango, inqanaba ledosi kunye neempendulo ezimbi zilinda.Oogqirha abachonga iithagethi zemfuza ezibandakanyekayo ekulawuleni uxinzelelo lwegazi kwizigulana zinokunceda ukulungelelanisa amayeza.
Ke ngoko, ukufunyaniswa kwe-polymorphisms yemfuza enxulumene neziyobisi kunokubonelela ngobungqina bemfuza obufanelekileyo bokhetho lwezonyango lweentlobo ezifanelekileyo zamachiza kunye needosi zamachiza, kunye nokuphucula ukhuseleko kunye nokusebenza kakuhle kokusetyenziswa kweziyobisi.
05 Inani labantu abasebenzayo kuvavanyo lwemfuzo lweyeza lomntu ngamnye loxinzelelo lwegazi
(1) Izigulane ezine-hypertension
(2) Abantu abanembali yentsapho yoxinzelelo lwegazi
(3) Abantu abaye baba nemiphumo emibi yeziyobisi
(4) Abantu abanesiphumo esibi sonyango lweziyobisi
(5) Abantu abafuna ukuthatha amachiza amaninzi ngexesha elinye
06 Izisombululo
IMacro & Micro-Test iphuhlise iikhithi zokubona i-fluorescence ezininzi ukuze zikhokele kwaye zichongwe amayeza oxinzelelo lwegazi, ebonelela ngesisombululo esipheleleyo nesibanzi sokukhokela amayeza ezonyango kunye nokuvavanya umngcipheko wokuchaphazeleka kakubi kweziyobisi:
Imveliso inokubona i-8 gene loci ehambelana neziyobisi ezichasene ne-antihypertensive kunye neeklasi ezi-5 eziphambili zeziyobisi (i-B adrenergic receptor blockers, i-angiotensin II receptor antagonists, i-angiotensin eguqula i-enzyme inhibitors, i-Calcium antagonists kunye ne-diuretics), isixhobo esibalulekileyo esinokukhokela amayeza ahlukeneyo ekliniki. kwaye uvavanye umngcipheko weziphumo ezibi kakhulu zeziyobisi.Ngokufumanisa ii-enzymes ze-metabolizing yechiza kunye nejene ekujoliswe kuyo kwichiza, oogqirha banokukhokelwa ukuba bakhethe amayeza afanelekileyo e-antihypertensive kunye nedosi kwizigulana ezithile, kunye nokuphucula ukusebenza kunye nokhuseleko lonyango lwechiza le-antihypertensive.
Kulula ukuyisebenzisa: usebenzisa iteknoloji ye-curve yokunyibilika, imithombo ye-2 yokusabela inokubona iindawo ezi-8.
Uvakalelo oluphezulu: owona mda usezantsi wokuchongwa yi-10.0ng/μL.
Ukuchaneka okuphezulu: Iisampuli ze-60 zizonke zavavanywa, kwaye iindawo ze-SNP zohlobo ngalunye zihambelana neziphumo zokulandelelana kwesizukulwana esilandelayo okanye isizukulwana sokuqala, kwaye izinga lokuphumelela lokufumanisa liyi-100%.
Iziphumo ezithembekileyo: Ulawulo lomgangatho wangaphakathi lunokubeka iliso kuyo yonke inkqubo yokufumanisa.
Ixesha lokuposa: May-17-2023