I-Mycobacterium Tuberculosis Nucleic Acid kunye neRifampicin Resistance

I-Mycobacterium tuberculosis , kungekudala njenge-Tubercle bacillus, i-TB, yintsholongwane ye-pathogenic ebangela isifo sephepha.Okwangoku, amachiza alwa nesifo sephepha asetyenziswayo odidi lokuqala aquka isoniazid, rifampicin kunye nehexambutol, njl. Nangona kunjalo, ngenxa yokusetyenziswa gwenxa kwamachiza okulwa nesifo sephepha kunye neempawu zesakhiwo sodonga lweseli yesifo sephepha se-mycobacterium, isifo sephepha se-mycobacterium siphuhlisa ukuxhathisa ichiza kumachiza okulwa nesifo sephepha, ezisa imingeni enzima kuthintelo kunye nonyango lwesifo sephepha.

I-Rifampicin isetyenziswe ngokubanzi kunyango lwezigulane ze-pulmonary tuberculosis ukususela ekupheleni kwe-1970s, kwaye inesiphumo esibalulekileyo.Kuye kwaba yinto yokuqala yokukhetha ukunciphisa i-chemotherapy yezigulane ze-pulmonary tuberculosis.Ukumelana ne-Rifampicin kubangwa ikakhulu kukuguqulwa kwejini ye-rpoB.Nangona amachiza amatsha okulwa nesifo sephepha ehlala ephuma, kunye nokusebenza kwezonyango kwizigulana zesifo sephepha semiphunga nako kuqhubekile ukuphucuka, kusekho ukunqongophala kweziyobisi ezichasene nesifo sephepha, kwaye isenzeko sokusetyenziswa kweziyobisi ngokungekho ngqiqweni ekliniki siphezulu.Ngokucacileyo, isifo sephepha seMycobacterium kwizigulane ezine-pulmonary tuberculosis ayikwazi ukubulawa ngokupheleleyo ngexesha elifanelekileyo, ekugqibeleni likhokelela kwiinqanaba ezahlukeneyo zokunganyangeki kweziyobisi emzimbeni wesigulane, kwandisa ixesha lesi sifo, kwaye kwandisa umngcipheko wokufa kwesigulane.