I-CYP2C19 yoMntu yeGene Polymorphism

I-CYP2C19 yenye yezobisi ezibalulekileyo ze-metabolizing enzymes kwintsapho ye-CYP450.Uninzi lwe-endogenous substrates kunye ne-2% yamachiza eklinikhi i-metabolism yi-CYP2C19, efana ne-metabolism ye-antiplatelet aggregation inhibitors (njenge-clopidogrel), i-proton pump inhibitors (i-omeprazole), i-anticonvulsants, njl. iziyobisi ezinxulumene.Olu tshintsho lwamanqaku e-*2 (rs4244285) kunye ne-3 (rs4986893) lubangela ukulahleka komsebenzi we-enzyme encoded yi-CYP2C19 gene kunye nobuthathaka besakhono se-metabolic substrate, kunye nokwandisa uxinzelelo lwegazi, ukuze kubangele ukusabela kakubi kweziyobisi ezinxulumene ne ugxininiso lwegazi.* I-17 (rs12248560) inokunyusa umsebenzi we-enzyme ekhowudiweyo yi-CYP2C19 gene, imveliso ye-metabolites esebenzayo, kunye nokuphucula i-platelet aggregation inhibition kunye nokwandisa ingozi yokopha.Kubantu abane-metabolism ecothayo yamachiza, ukuthatha iidosi eziqhelekileyo ixesha elide kuya kubangela ityhefu eyingozi kunye nemiphumo emibi: ikakhulu umonakalo wesibindi, umonakalo we-hematopoietic system, umonakalo we-nervous system, njl., onokukhokelela ekufeni kwiimeko ezinzima.Ngokweyantlukwano yomntu ngamnye kwimetabolism yeziyobisi ehambelanayo, ihlulwe ngokubanzi ibe ziiphenotypes ezine, ezizezi: i-Ultra-fast metabolism (UM, *17/*17,*1/*17), imetabolism ekhawulezayo (RM, *1/*1) ), i-metabolism ephakathi (IM, *1/*2, *1/*3), i-metabolism ecothayo (PM, *2/*2, *2/*3, *3/*3).